Welcome

Welcome to the Systems Biology Laboratory at the University of Melbourne.

At the Systems Biology Lab we build and analyse mathematical models of biological processes, pathways and networks, and the cellular geometries within which these processes take place. We apply these models to problems in human health and physiology, including cancer and heart disease.

The Systems Biology Lab is made up of several research groups – more details can be found on these pages and through links to individual research group websites.

For more information contact Professor Edmund Crampin

edmund.crampin@unimelb.edu.au

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Postdoctoral Opportunities

3 Open Postdoctoral Positions at the Systems Biology Lab

1) Research Fellow in Cardiac Systems Biology

You will develop biophysically realistic and structurally detailed computational models of calcium signaling in heart cells, at scales from molecular through to whole-cell models. As part of an international interdisciplinary team including modellers, biophysicists, bioimaging experts and physiologists, you will develop models to gain mechanistic insights into the role of sub-cellular calcium dynamics in diseases such as cardiac hypertrophy and diabetic cardiomyopathy. Familiarity with one or more of the following areas would be advantageous: modelling and simulation of spatial and/or stochastic systems, finite element modelling, stochastic processes, calcium signalling, cardiomyocyte physiology.

The Research Fellow will be supervised by Prof. Edmund Crampin and Dr. Vijay Rajagopal, as part of an ARC Discovery Project ‘How does calcium make the heart grow?’.

University of Melbourne Job no: 0043044
Closing date: 9 May 2017
http://jobs.unimelb.edu.au/caw/en/job/890506/research-fellow-in-cardiac-systems-biology

2) Research Fellow in Computational Systems Biology

You will develop standards and approaches for integrative computational modelling to understand the interactions between nano-scale materials and cells. As part of a highly interdisciplinary and collaborative team at the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and across several Australian universities, the project aims to better understand and hence predict how properties of nano-engineered particles for drug delivery determine cellular recognition, uptake and processing. Knowledge of systems biology standards, databases and use of computational modelling to interpret experimental data would be advantageous, along with confidence and willingness to bring mathematical and computational approaches into a highly collaborative research cluster.

The Research Fellow will be supervised by Prof. Edmund Crampin, in collaboration with other investigators in the ARC Centre of Excellence in Convergent Bio-Nano Science & Technology.

University of Melbourne Job no: 0043121
Closing date: 14 May 2017
http://jobs.unimelb.edu.au/caw/en/job/890565/research-fellow-in-computational-systems-biology

3) Research Fellow in Energy-based Modelling for Systems Biology

The Research Fellow will undertake research to develop an energy-based approach to modelling cellular processes. Most current systems biology models consider networks of biochemical reactions in terms of fluxes, or reaction rates. This provides a very incomplete description as it ignores the flow of energy through the system. Energy is fundamental to all biological systems and processes. The aim of the research project is to develop new approaches with which to represent energy flows in biochemical processes, in addition to fluxes, using bond graphs. In particular this approach will be applied to analysis of heart cells, as part of the ‘cardiac cell physiome’ project. Desirable skills include experience working with large systems of nonlinear ODEs, knowledge of and interest in thermodynamics, familiarity with markup languages (such as CellML and SBML).

The project will be supervised by Prof. Edmund Crampin and Prof. Peter Gawthrop.

University of Melbourne Job no: 0043120
Closing date:  14 May 2017
http://jobs.unimelb.edu.au/caw/en/job/890563/research-fellow-in-systems-biology

 

For more information contact Professor Edmund Crampin
edmund.crampin@unimelb.edu.au

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